A po-boy shop in a converted Uptown house that has been serving fried seafood sandwiches to the neighbourhood since 1929, run by generations of the Domilise family with the particular stubbornness of people who know they are doing one thing perfectly and see no reason to do anything else. The fried oyster and fried shrimp po-boys are the essential orders — the seafood is impeccably fresh, the batter is crispy without being heavy, and the bread is the correct Leidenheimer that every po-boy in the city should use but not every po-boy does. The space is tiny, the decor is minimal, and the focus is total.
Location
Uptown, New Orleans
Insider Intel
Fried oyster po-boy or fried shrimp po-boy — these are the two orders that define Domilise's and the ones that justify the trip to deep Uptown. The seafood is perfectly fried: hot, crispy, and yielding inside. Hot sauce on the side. The roast beef is also good but you came here for the seafood.
Lunch — the restaurant operates during the day and closes in the afternoon. Arrive before the noon rush if you can. The small space means the wait can be significant during peak hours.
Cash only. The Uptown location on Annunciation Street is residential and deep in the neighbourhood — plan a rideshare or drive. Miss Dot Domilise ran the shop for decades; the family continues. The space is a converted house and feels like one, which is part of its appeal. Do not expect atmosphere; expect a perfect po-boy in a room that exists for no other purpose.